Differences in inclusion criteria, patient demographics, and study design could account for these discrepancies, yet nonetheless evidence exists that GLP-1 activity likely influences mesolimbic signaling through a complex and not yet fully understood mechanism
Meanwhile, older members of the drug class such as exenatide and lixisenatide have also been shown to be capable of penetrating into the brain and previous small trials have suggested potential benefits to people with Parkinsons disease
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Riboflavin Has Neuroprotective Potential: Focus on Parkinsons Disease and Migraine
Journal of Integrative Medicine , 13 (4), 231240