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coli (S4, S7, S8, S16, S18, and L11) conducted in 1978 by Khechinashvili et al., it was concluded that although S4, S7, S8, S16, and L11 possessed a cooperative tertiary structure in solution as evidenced by their cooperative melting, S18 did not show conformational transitions in the range of 10100 C, suggesting that this protein was disordered (Khechinashvili et al., 1978)

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The clustering between specific biological and clinical features has been postulated to identify a theoretical dimension labelled immuno-metabolic depression (IMD) [2] (aligning with the Research Domain Criteria (RDoC) framework [52]

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The landscape of endocrine research is shifting rapidly, moving away from blunt hormonal replacements toward more nuanced, regulatory signaling