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Exacerbations lead to loss of lung function, exposure to systemic corticosteroids, effects on quality of life, and even mortality

Dose can be increased in 2.5 mg increments every four weeks to a maximum of 15 mg weekly

Nat Rev Drug Discov

Figure 6 Mitochondrial Functional Markers There was no significant difference in MnSOD, Tom-20 and OXPHOS complexes among the three groups at P1 (Figures 7A,D,G)