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10.1530/eje.0.1340362 139

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Systemic liraglutide administration activated LS GLP-1R neurons, and the knockdown of GLP-1Rs in the LS mitigated the anti-obesity effects of liraglutide

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Variants in FTO (fat-mass and obesity-associated), GLP1R (the GLP-1 receptor gene), MC4R (a satiety-linked melanocortin receptor), and TCF7L2 (tied to glucose homeostasis) describe the baseline metabolism into which a dual agonist is introduced

The use of human islets was exempt, as cadaveric specimens without unique identifying information were used