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These observations support a paradigm, in which Ca 2+ /CaSR signaling counteracts PTHrP/PTH1R signaling by suppressing PTH1R expression, independently, of IGF1/IGF1R signaling and by inhibiting PTHrP expression via the IGF1/IGF1R pathway to support normal progression of chondrocyte differentiation and growth plate development (Figure 1)
Mallhi, Z
PubMed PMID: 18071657
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In addition, individual compounds of the herbal extracts are barely studied even in experimental animal models
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