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In some embodiments, the otic formulation or composition comprises about 0.1% by weight of the silicon dioxide

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doi:10.1016/j.bone.2005.04.017

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Chem Rev 121:32973351 White BH, Whalen K, Kriksciukaite K, Alargova R, Au Yeung T, Bazinet P, Brockman A, DuPont M, Oller H et al (2019) Discovery of an SSTR2-targeting maytansinoid conjugate (PEN-221) with potent activity in vitro and in vivo

Metabolic-dysfunction and obesity-pathway preclinical investigations