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Causal impact of human blood metabolites and metabolic pathways on serum uric acid and gout: a Mendelian randomization study

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The phosphorylation state of MLC-2 therefore reflects a dynamic balance between MLCK-mediated phosphorylation and MLCP-mediated dephosphorylation, with increased phosphorylation generating ATP-dependent actomyosin contraction and elevated cytoskeletal tension at the apical junctional complex (Jin and Blikslager, 2020)

The article uses the rule that complete elimination takes roughly four to five half-lives

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Treat the schedule above as reported use, not a recommendation