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The consumption of glutamine by the cancer cells in clear cell renal cell carcinoma (ccRCC) results in the local deprivation of extracellular glutamine This, in turn, triggers the release of IL-23 by cancer-infiltrating macrophages via the activation of hypoxia-inducible factor 1 (HIF1) [71]

Ontogeny of glutamine synthetase in rat small intestine

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Therefore, we may be capturing a susceptible period, in middle age, for weight gain in females, directed towards increased fat storage in their visceral depots

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