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Additionally, while preclinical studies have demonstrated encouraging results, most research remains in early stages, and the lack of reliable biomarkers for monitoring ferroptosis complicates clinical application

Oxidative stress has been linked to male and female infertility, as well as complications during pregnancy

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In the closed state of Pa DHDPR, the interaction surface between the N- and C-terminal domains can be divided into two components: one for the interaction mediated by NADPH and DPA, and another for the interaction mediated by the 7 helix (Fig