While most clinical evidence supports a favorable safety profile at typical therapeutic doses, caution is warranted as higher doses may cause sedation, cardiovascular effects such as hypotension and arrhythmias, and, in rare cases, respiratory depression
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Prior health conditions You may not be a good candidate for GLP-1 agonists, depending on your health history
That being said, over 70% of Americans are overweight or have obesity, so even if anxiety and depression reductions are driven by weight loss and dont occur in lower weight individuals, a majority of the population may still see benefits in mental health
Among participants on the 15 mg dose, 57% achieved 20% or greater weight reduction