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In different cell types, activation of necroptosis can be triggered by death receptors of the TNF family, including TNF receptor superfamily member 1A (TNFRSF1A/TNFR1), FAS, and TNF-related apoptosis-inducing ligand (TRAIL) receptors (TNF receptor superfamily member 10a [TNFRSF10A/TRAILR1] and TNF receptor superfamily member 10b [TNFRSF10B/TRAILR2]), that typically induce apoptosis
Rodrigues-Pereira R, Scholte HR, Luyt-Houwen IE, Vaadrager-Verduin MH
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Therefore, to understand the real-time dynamics of cellular GSH in vivo , a non-invasive visible reporter is needed
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