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A 2009 study published in Endocrine Reviews found that melanocortin receptor agonists produce dramatically different clinical profiles depending on which receptor subtypes they activate
Graphical abstract was made using BioRender software
Higher incident psoriasis risk versus DPP-4 inhibitors, lower risks of pemphigus (HR 0.32) and bullous pemphigoid (HR 0.61), and no significant differences for other inflammatory or autoimmune skin outcomes after multiple-testing correction
However, the absolute risk remains very low the European Medicines Agency estimates fewer than 1 in 10,000 patients will develop NAION
7 A history of these issues may be a reason for caution
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