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Ischemic postconditioning has been explored as a strategy to alleviate limb IR-induced renal injury, with studies revealing notable histopathological alterations in kidney tissues post injury [13]

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doi: 10.1161/HYPERTENSIONAHA.118.12389 138 KellyB.PearceE

The copper binds via the histidine imidazole ring, the peptide backbone, and deprotonated amide nitrogens, forming a stable, square-planar coordination complex