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If Pendulum GLP-1 Probiotic Pro can meaningfully increase natural GLP-1 production, the downstream anti-inflammatory benefits could extend well beyond appetite control
Oral formulations have a shorter half-life.[ref] In clinical trials, GLP-1 RAs improved lipid profiles, increased satiety, slowed gastric emptying, reduced inflammation, and had neuroprotective effects.[ref] The slowing of gastric emptying and reducing inflammation may play a role in weight loss, along with the decrease in appetite and eating less
Retatrutide is an investigational triple agonist that simultaneously activates GLP-1, GIP, and glucagon receptors, enhancing insulin secretion, suppressing appetite, increasing energy expenditure, and promoting hepatic fat oxidation
Campbell JE, Drucker DJ (2013) Pharmacology, physiology, and mechanisms of incretin hormone action
Ricks said shots haven't been as big of a barrier to uptake as Lilly once thought they would be
The largest phase 2 study published on retatrutide, which included 338 non-diabetics, indicated comparable side effects
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