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Clarke, In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(-)-carvedilol

These molecules can bind to the cellular proteins and DNA and can alter the function of both exciting adduct formations [14, 120]

911,13,14 Organelle swelling leads to cellular necrosis and the release of mitochondrial contents, such as apoptosis-inducing factor (AIF) and endonuclease G (EndoG), which in turn migrate to the nuclei and cause DNA fragmentation

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147,148,149,150 The abnormal body composition is characterized by increased adipose tissue mass, decreased lean body mass, decreased muscle mass and strength

doi: 10.1016/0047-6374(89)90022-5