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Direct cartilage-, synovium-, or bone-modifying effects remain insufficiently established in humans, and the available evidence is still limited by sparse KOA-specific trials, short-to-medium follow-up, limited structural endpoints, and uncertainty regarding long-term safety, adherence, affordability, and surgical outcomes

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Dementia risk is complex, and GLP-1 therapy has risks, contraindications, and monitoring needs

V.et al (2012)

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While there is no data to establish the safety of 5-amino-1MQ in humans, rodent studies have found no significant adverse effects [1, 6, 11]