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Metabolic Flexibility and Substrate Utilization Dual agonism may promote greater metabolic flexibility by influencing both glucose and lipid metabolism through complementary mechanisms

Cancer 30 (4), e220184

First, in pivotal trials of GLP-1 RAs, there is no acute decrease in GFR that would be expected with proximal natriuresis, suggesting that there is minimal renal hemodynamic response to GLP-1 RAs

Beta-oxidation occurs in the liver, specifically in the mitochondria, where they are transformed into triglycerides and exported to the systemic circulation as constituents of very-low-density lipoproteins

Better cardiovascular fitness from weight loss and increased activity