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2 GLP-1R GLP-1R is a G protein-coupled receptor (Wu et al., 2020) (Figure 1A)

Fifth, previous CVOTs have suggested that the beneficial effects of GLP-1 RAs are primarily associated with long-acting agents such as liraglutide, semaglutide, and dulaglutide, rather than short-acting agents like exenatide and lixisenatide [17, 54, 56, 57, 68]

GLP-1 medications work by mimicking gut hormones that regulate insulin secretion, slow gastric emptying, and reduce appetite through central nervous system effects

Scand J Immunol

For semaglutide, that means jumping from 0.25 mg to 0.5 mg