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Proc Natl Acad Sci U S A 1996

Information for Patients: Patients with pernicious anemia should be informed that they will require monthly injections of vitamin B12 for the remainder of their lives

Reductive carboxylation supports growth in tumour cells with defective mitochondria

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Rolo AP, Teodoro JS & Palmeira CM 2012

However, some people experience mild stomach discomfort with empty stomach dosing, in which case taking with a small amount of food is acceptable