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Basu R, Shah P, Basu A et al (2008) Comparison of the effects of pioglitazone and metformin on hepatic and extra-hepatic insulin action in people with type 2 diabetes

Many clinical trials have reported gastrointestinal side effects as among the most common side effects of GLP-1 receptor agonists, contributing to decreased fluid intake

Edema, orthostatic hypotension, myositis, carpal tunnel, and gynecomastia have also been reported during GH administration to frail elderly (Cohn, Feller, Draper et al., 1993, Sullivan, Carter, Warr et al., 1998) while carpal tunnel and hyperglycemia were reported during GH administration to healthy adults (Blackman, 2004)

i went from 58kgs to 64 in that time

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Increased oxidative stress, disrupted mitochondrial respiration, and neuronal energy imbalance are closely linked to the neurotoxic effects of glutamate (Brown and Vilalta 2015)