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Mechanistically, HGF-induced synapse formation is mediated by PI-3K and not MAPK activation, as inhibition of the PI-3K/AKT pathway affects synaptogenesis, while blocking MAPK/ERK does not decrease synapse density and only affects dendritic growth (Peng et al., 2016)

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A 2018 systematic review & meta-analysis out of Nutrition Reviews determined that the effective dose required for this effect, based on studies reviewed, was 3 grams per day of EPA/DHA combined