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Evidence of direct depletion: Weak Mechanistic plausibility via reduced intake: Moderate Symptoms of B12 Deficiency Neuropathy Fatigue Brain fog Macrocytic anaemia Persistent fatigue during GLP-1 therapy can have multiple causes, including caloric restriction and micronutrient shifts

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These weight-loss measurements are lower than those recorded for other GLP-1 drugs, such as semaglutide, which are reported to result in mean weight reductions of 1520% and beyond