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Researchers observed reversals in the positive effects from GLP-1s, including reduced cardiovascular risk, and lower blood sugar, cholesterol and blood pressure levels

Pharmaceuticals (Basel) 17(12):1655 [DOI] [PMC free article] [PubMed] [Google Scholar] 70.Picoli CC, Tsibulnikov S, Ho M, Demambro V, Feng T, Eltahir M, Le PT, Chlebek C, Rosen CJ, Ryzhov S, Li Z (2025) Vertical sleeve gastrectomy and semaglutide have distinct effects on skeletal health and heart function in obese male mice

Neuron 85(5):942958

223,224 GLP-1 also inhibits glucagon release from -cells, which is beneficial for reducing blood glucose levels since glucagon promotes hepatic gluconeogenesis

Dosing schedules for GLP-1 medications are established through clinical trials that evaluate efficacy, safety, and patient adherence

If side effects become severe, speak to your prescriber about adjusting your treatment