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Wilson JM, Lin Y, Luo MJ, et al

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In 2010, Mitchell and colleagues examined the molecular mechanism of palmitate transfer of the yeast Ras PAT by combining genetic and biochemical methods, and found that the palmitoylation reaction occurs in a two-step manner consisting of autopalmitoylation of the DHHC containing enzyme to create a palmitoyl-Erf2 intermediate, followed by transfer of the palmitoyl group to Ras2 ( Figure 1A )

Dysregulated Epicardial Adipose Tissue as a Risk Factor and Potential Therapeutic Target of Heart Failure with Preserved Ejection Fraction in Diabetes

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