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FIGURE 1 3.1.1 Transcriptional and post-translational regulation Chac1 is a novel pro-apoptotic factor induced by ER stress

The loading phase builds antioxidant stores through frequent sessions over several weeks

Clinical evidence links elevated HKII expression to advanced CRC features including tumor volume, invasion depth, staging, and lymph node metastasis, establishing its dual role as both a prognostic marker and therapeutic target

The dose can be increased in 2.5mg increments every 4 weeks as needed for glycemic control, with a maximum dose of 15mg

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If you use a continuous glucose monitor (CGM), review your data regularly and watch for upward trends in your average glucose and time in range