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Amoros M, Lurton E, Boustie J, Girre L, Sauvager F, Cormier M

It works by slowing gastric emptying, stimulating insulin release in response to food, and signaling the brain's satiety centers to reduce hunger

Neuropharmacology 86 , 241258 (2014)

Indeed, insulin sensitizers are all inhibitors of mitochondrial complex I [84, 175], resulting in suppressing mitochondrial electron flux and oxidative phosphorylation, with increase in metabolic stress and AMPK [176, 177]