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Future Directions: Research is expanding beyond weight loss to evaluate CagriSema's effects on cardiometabolic complications (cardiovascular disease, NASH, sleep apnea, HFpEF), special populations (adolescents, diverse ethnic groups), and quality of life outcomes

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The development of colorectal cancer liver metastases depends on complex tumor-stroma interactions and a supportive metastatic niche

showed that the pelvic iron-overloaded environment in patients with endometriosis impaired early embryonic development and caused embryo toxicity by triggering GPX4 downregulation-dependent ferroptosis in preimplantation mouse embryos