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GRK2 Mediated Abnormal Transduction of PGE2-EP4-cAMP-CREB Signaling Induces the Imbalance of Macrophages Polarization in Collagen-Induced Arthritis Mice

The peak expression of mRNA for the egr-1 co-repressor, nerve growth factor 1-A binding protein-2 (nab2), was observed 30 min after BPC 157 stimulation (Tkalcevic et al., 2007)

Maintenance Phase: Monthly Injections After the loading phase, patients move to a maintenance phase

Strinic D, Belosic Halle Z, Luetic K, Nedic A, Petrovic I, Sucic M, Zivanovic Posilovic G, Balenovic D, Strbe S, Udovicic M, Drmic D, Stupnisek M, Lovric Bencic M, Seiwerth S, Sikiric P

However, no large-scale human clinical trials have confirmed these effects, so its use in people remains experimental and off-label