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On either pill the frequent reactions are gastrointestinal: nausea, vomiting, and diarrhea, along with constipation, abdominal pain, indigestion, bloating, belching and gas, and reflux or heartburn

The B12-intrinsic factor complex travels to the terminal ileum where specific receptors mediate absorption

Moreover, patients with IBS exhibited an enrichment of bacterial taxa, such as Enterobacteriaceae, Streptococcus, Fusobacteria, Gemella , and Rothia , as well as depletion of health-promoting bacterial genera, such as Roseburia and Faecalibacterium (Sciavilla et al., 2021)