These results are based on studies of branded medications in people without diabetes with BMI 30, or BMI 27 plus a weight-related condition when paired with diet and exercise changes
Cardiovascular and Mortality Outcomes with GLP-1 Receptor Agonists in Patients with Type 2 Diabetes: A Meta-Analysis with the FREEDOM Cardiovascular Outcomes Trial
doi:10.36849/JDD.8605
That said, musculoskeletal symptoms including joint discomfort, arthralgia, and back pain have been observed across the broader class of incretin-based therapies
1041 Derivation of a preference-based value set for the Short Warwick-Edinburgh Mental Well-being Scale (SWEMWBS) to allow calculation of Mental Well-being Adjusted Life Years (MWALYs) Hei Hang Edmund Yiu 1 , Stavros Petrou 2 , Sarah Stewart-Brown 3 , David Churchman 4 , Jason Madan 3 1 Department of Pharmacology and Pharmacy LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong, 2 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK, 3 Warwick Medical School, University of Warwick, Warwick, UK, 4 InSpired Health Outcomes, Witne, UK Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :1041 Aims Concerns have been raised about the sensitivity of widely used preference-based instruments, such as the EQ-5D, in valuing mental health benefits
Glucagon is typically known as the hormone that raises blood sugar, so its inclusion seems counterintuitive
