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In this final rule with comment period, we reinforce our requirement that hospitals must calculate and encode a payer-specific negotiated charge dollar amount when possible and, when the payer-specific negotiated charge is based on an algorithm or percentage, must do more than merely offer a good faith effort to enter their payer-specific negotiated charge percentage or algorithms

The Lancet, 391(10118), 309318

Your provider will help you decide based on your labs, your goals, and how your body is responding

However, this practice is still not well-studied, so many physicians advise against it