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78 These DAMPs act as danger signals that activate innate immune receptors, including pattern recognition receptors

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Although only three anti-estrogenic substances banned by WADA were identified in this study, clomiphene, tamoxifen, and raloxifene, it should be remembered that other banned substances from the S4.2 group, such as bazedoxifene, cyclofenil, fulvestrant, ospemifene, or toremifene, may also be present in illegal samples purchased by athletes (Okano et al., 2022)

They may work reasonably well for GI issues or systemic support, but bioavailability is less predictable