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Proteins 42 , 108124 (2001)

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(iii) GSH is activated by the glutaredoxin and catalysis requires a ternary complex with the disulfide substrate 30,34

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In oral cancer, IGFBP-2 promotes the upregulation of matrix metalloproteinase (MMP)2 and MMP9 through the activation of the PI3K/Akt/mTOR signaling pathway, which ultimately leads to the proliferation, migration and invasion of cancer cells (29)