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Por ello se precisan frmacos con un potente efecto antihiperglucemiante, independiente del filtrado glomerular, con bajo riesgo de hipoglicemia, que reduzcan el peso en pacientes con sobrepeso/obesidad y que proporcionen una proteccin cardiovascular y renal, como los agonistas del receptor de GLP-1
[3] Some preclinical studies suggest GLP-1 may have beneficial effects on pancreatic beta cells, though long-term preservation of function in humans remains unproven
5E, we found that metformin, at different concentrations and treatment durations, did not induce RINm5F cell death
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Leptin sensitivity improves as fat mass decreases