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Overcoming the drug resistance of MET-TKIs and ICIs, as well as their toxic and side effects that may affect the drug efficacy, remains a critical challenge

REDEFINE 1: Strong Results, Missed Ambitions The first pivotal trial, REDEFINE 1, enrolled 3,417 adults with obesity or overweight and at least one weight-related comorbidity, but without type 2 diabetes

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