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Calcium ions (Ca 2+ ) are central mediators of both physiological and pathological smooth muscle contraction, as well as targets of the pharmacological action of numerous agents (Williams D
Because of this, toxicity from dietary sources is uncommon
Am J Clin Nutr 93(4):884s-s890 McGee SL, van Denderen BJ, Howlett KF, Mollica J, Schertzer JD, Kemp BE et al (2008) AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5
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reported that activation of the NLRP3 inflammasome, including increased mitochondrial superoxide production and lipid peroxidation, may persist after short-term patient recovery [80]