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doi: 10.1016/j.amjcard.2013.09.021 3 AokiK.UchiharaT.SanjoN.NakamuraA.IkedaK.TsuchiyaK.et al

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NRF2 orchestrates the upregulation of several antioxidant genes reliant on GSH, including GSR, solute carrier family 7 member 11 (SLC7A11), glutamatecysteine ligase catalytic subunit (GCLC), and glutamatecysteine ligase modifier subunit, as well as metabolic detoxification genes such as aldehyde dehydrogenase 1 family member A1 and aldoketo reductase family 1 member C1 in cancer cells [66]

However, endogenous GLP-1 is also produced by preproglucagon (PPG) neurons in the brain (Holt et al., 2019

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