Hepatic enzymes (cytochrome P450 oxidases, glucuronosyltransferases) metabolise and conjugate the compound, reducing the amount that reaches target tissues
The raw proteomic data and the processed and harmonized proteogenomic data for the study cohort are available through the Proteomic Data Commons under accession numbers PDC000554, PDC000555, PDC000556, PDC000557, PDC000558, PDC000559, PDC000560, PDC000561 and PDC000562
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A study by Naidoo and colleagues showed that patients who received checkpoint inhibitor combination therapy tended to have a shorter onset time to adverse events than those who received checkpoint inhibitor monotherapy
Wang C, Dong S, Zhang L, Zhao Y, Huang L, Gong X, et al
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