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Continued research is needed to discover more mitochondria-targeted drugs and develop innovative technologies and strategies

doi: 10.1016/j.trecan.2021.04.003 212 SuzukiSTanakaTPoyurovskyMVNaganoHMayamaTOhkuboSet al

Vitamin B7 (Biotin) : Contributes to the metabolism of carbohydrates, fats, and proteins

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ERR target-gene expression (for example, Ppargc1a, Tfam, OXPHOS subunits), oxygen-consumption rate in cells, and, in vivo, indirect calorimetry parameters (energy expenditure, RER), plus mitochondrial DNA and cytochrome-c content in muscle

However, the findings that the stable gastric pentadecapeptide BPC 157 might beneficially affect striated and smooth muscle and heart might suggest that it most perfectly matched [32,33,34] with the original Roberts and Szabos cytoprotective theory and concept [35,36,37,38,39,40,41,42]