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DOX is a highly toxic molecule and induces drug resistance due to the overexpression of ABCB1 efflux pump and other related proteins 127

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These include HSPB1 (HSP27), HSPB5 (B-crystallin), HSPB6 (HSP20), HSPB7 (cardiovascular HSP), and HSPB8 (HSP22)

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