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21 Advanced neurologic symptoms may not respond to replacement

The inhibition of H3R via H3R antagonists enhances histamine release, thereby suppressing the neuroinflammatory effects of microglia and preventing dopaminergic neuronal degeneration [58,61]

Most patients on either drug don't reach either extreme, but the distribution skews differently tirzepatide pulls the curve toward Depletive, semaglutide skews toward Prime

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