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Importantly, a clinical study has demonstrated that combining radiotherapy with higher doses of the TGF-blocking antibody fresolimumab (10 mg/kg) increases overall survival significantly in metastatic breast cancer patients compared to those undergoing radiotherapy and receiving lower doses of fresolimumab (1 mg/kg) [135]

They might need special dosing because of aluminum toxicity and clearance issues

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TB-500 is a synthetically made iteration of thymosin beta-4, a naturally occurring peptide consisting of 43 amino acids

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High dose oral cobalamin may be a suitable alternative in selective cases, where intramuscular injections are not tolerated and compliance is not a problem