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These are not small differences

Ozempic and Rybelsus are approved for type 2 diabetes, and Wegovy is primarily indicated for weight management in obese and overweight patients, when used along with healthy lifestyle modifications and caloric restrictions

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Retatrutide needs Phase 3 data, FDA approval, cardiovascular outcomes studies, and years of post-market surveillance before it can match semaglutide's evidence base

Adding once-daily lixisenatide for type 2 diabetes inadequately controlled by established basal insulin: a 24-week, randomized, placebo-controlled comparison (GetGoal-L) Diabetes Care