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Handling should be carried out by qualified personnel in appropriate laboratory conditions

However, the in vivo potency was lower than that of topiroxostat, which could be explained by the poor absorption found in the parallel artificial membrane permeability assay [77]

Thus, only about 50% of a rectal dose can be assumed to bypass the liver

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Creating a truly sterile solution with a precise 0.9% benzyl alcohol concentration requires specialized equipment and a sterile environment that is not present in most labs