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Semaglutide 2.4 mg reduced the rate of major adverse cardiovascular events (MACE: cardiovascular death, nonfatal myocardial infarction, nonfatal stroke) by 20% compared to placebo (HR 0.80

According to FDA prescribing information, the most common side effects include nausea, vomiting, diarrhea, and constipation, particularly during dose escalation

According to the previously accepted two-hit theory, the development of this disease occurs in two stages

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