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Colorectal Cancer Metastatic dMMR Immunotherapy (COMMIT) study: A randomized phase III study of atezolizumab (atezo) monotherapy versus mFOLFOX6/bevacizumab/atezo (FFX/bev) in the first-line treatment of patients (pts) with deficient DNA mismatch repair (dMMR) or microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) NRG-GI004/SWOG-S1610

Here, a generalized linear mixed effects model was utilized to adjust for repeated measures within the same subjects to compare between low free carnitine and normal free carnitine groups

Older adults, those taking concurrent medications affecting gut motility, and individuals with slower metabolic rates may also show heightened responses

and Garg et al

S.van GroenT.et al (2010)

In other words, even with adequate oxygen and glucose supply, neurons are unable to effectively utilize these substrates for oxidative phosphorylation