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Structural Stability There's another benefit: some peptides undergo deamidation at neutral or basic pH asparagine residues slowly convert to aspartate, which degrades the peptide's activity over time

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This process apparently starts when the VEGF protein, which is considered to be secreted by oxygen-deprived cells during a hypoxic response, and may bind to VEGF receptors on the surface of endothelial cells

1996 May;53(5):441-8

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