Yi et al., 2021), and in animal studies ( The second finding was that cognitive improvement after OLA treatment was significantly associated with decreased levels of 2-octenoylcarnitine and butyrylcarnitine in schizophrenia
Recent Findings GLP-1 RAs modulate insulin signaling, reduce neuroinflammation and oxidative stress, and improve mitochondrial functional mechanisms linked to neuroprotection
Journal of Biomedicine and Biotechnology, 2011 , 937617
We do not know what fraction reaches systemic circulation in humans, and "detectable GI effect" does not equal "adequate systemic bioavailability for joint repair." The acetate salt versus free acid labeling problem
Oral therapies, if effective, could be game changers for patients hesitant about weekly injections
Additionally, Wegovy is FDA approved to lower the risk of major cardiovascular eventsincluding stroke, heart attack, and deathin adults with cardiovascular disease and either obesity or overweight