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Ascorbyl palmitate (AP) is an ester formed from ascorbic acid and palmitic acid creating a form of vitamin C that is fat-soluble, meaning it can interact with lipid-based molecules

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The production of NO by NOS2 (in micromolar amounts) is much higher and more sustained than by other NOSes, thereby making NOS2 an important player in regulating inflammation and infection (28, 32)

Together, excessive and reduced production of neuro-toxic and -protective kynurenines, respectively, may exacerbate excitotoxicity and neuroinflammation, establishing a feed-forward cycle of KP dysregulation, 5-HT depletion, HPA axis hyperactivity, and increased vulnerability to MDD