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Mechanism 6: Diuretic and natriuretic effects GLP-1 receptor agonists have documented diuretic and natriuretic properties
A PROMIS T -score of 50 best differentiates clinically meaningful fatigue in the oncology population ( T -score 50) was reported by 40% of participants in the +ADT group (PROMIS T -score: 47.92 7.28) compared to 24% of the ADT group (PROMIS T -score: 44.34 7.81) (Figure 4A, p = 0.0064)
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Researchers then split them into four groups for one full year: Group 1: Exercise only (no medication) Group 2: Liraglutide only (a GLP-1 medication, 3.0 mg daily no structured exercise) Group 3: Exercise + liraglutide (both together) Group 4: Placebo + no exercise (control group) Here is what happened after one year: Exercise alone: Lost 4.1 kg (about 9 lbs) Medication alone: Lost 6.8 kg (about 15 lbs) Exercise + medication: Lost 9.5 kg (about 21 lbs) Placebo: Regained weight The combination group lost approximately 40% more weight than the medication-alone group, and nearly 2.5 times more than exercise alone
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